Extracting drug-enzyme relation from literature as evidence for drug drug interaction.

Journal: Journal of biomedical semantics
Published Date: Mar 7, 2016

Abstract

BACKGROUND: Information about drug-drug interactions (DDIs) is crucial for computational applications such as pharmacovigilance and drug repurposing. However, existing sources of DDIs have the problems of low coverage, low accuracy and low agreement. One common type of DDIs is related to the mechanism of drug metabolism: a DDI relation may be caused by different interactions (e.g., substrate, inhibit) between drugs and enzymes in the drug metabolism process. Thus, information from drug enzyme interactions (DEIs) serves as important supportive evidence for DDIs. Further, potential DDIs present implicitly could be detected by inference and reasoning based on DEIs.

Authors

  • Yaoyun Zhang
    Alibaba Damo Academy, 969 West Wen Yi Road, Yu Hang District, Hangzhou, Zhejiang, China.
  • Heng-Yi Wu
    School of Medicine, Indiana University, Indianapolis, IN USA.
  • Jingcheng Du
    University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Jun Xu
    Department of Nephrology, The Affiliated Baiyun Hospital of Guizhou Medical University, Guizhou, China.
  • Jingqi Wang
    School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Cui Tao
    The University of Texas Health Science Center at Houston, USA.
  • Lang Li
    Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
  • Hua Xu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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