Optimization of Melatonin Dissolution from Extended Release Matrices Using Artificial Neural Networking.
Journal:
Current drug delivery
Published Date:
Jan 1, 2016
Abstract
BACKGROUND: Efficacy of melatonin in treating sleep disorders has been demonstrated in numerous studies. Being with short half-life, melatonin needs to be formulated in extended-release tablets to prevent the fast drop of its plasma concentration. However, an attempt to mimic melatonin natural plasma levels during night time is challenging.