International journal of pharmaceutics
Dec 5, 2025
Mathematical modeling is becoming increasingly important in the pharmaceutical industry. It supports the Quality by Design framework by aiding process understanding and examining the impact of critical material and process parameters on the critical ...
International journal of pharmaceutics
Oct 27, 2025
Assessing the feasibility of a manufacturing route for a given formulation and process is a key initial step in drug product development. Additionally, the final product must meet a series of critical quality attributes to be considered suitable to m...
International journal of pharmaceutics
Oct 13, 2025
The disintegration behaviour of pharmaceutical tablets is a critical quality attribute influencing drug release, yet predicting it from formulation and processing parameters remains challenging due to complex underlying mechanisms. This work presents...
International journal of pharmaceutics
Sep 19, 2025
Ribbon splitting, a phenomenon that can occur during the roller compaction operation used in dry granulation processes, can lead to compromised granule uniformity, poor tabletability, and ultimately, off-specification tablet production. Despite its i...
Direct compression (DC) remains a popular manufacturing technology for producing solid dosage forms. However, the formulation optimisation is a laborious process, costly and time-consuming. The aim of this study was to determine whether machine learn...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Jun 11, 2025
Pharmaceutical manufacturing has surged in drug development with the rise of Pharma 4.0, leveraging artificial intelligence (AI) to improve efficiency, optimize resource use, and reduce production times. Direct Tablet Compression (DTC), a key manufac...
Journal of pharmaceutical and biomedical analysis
Apr 29, 2025
The prevalence of falsified medications remains a global health challenge, intensified by globalization, internet accessibility, and the high profitability associated with low risks for this type of trafficking. This study demonstrates the innovative...
This research assesses multiple predictive models aimed at estimating disintegration time for pharmaceutical oral formulations, based on a dataset comprising nearly 2,000 data points that include molecular, physical, compositional, and formulation at...
British journal of clinical pharmacology
Apr 7, 2025
AIMS: The incidence of osteoporosis is projected to exceed 70 million people over the age of 65 years by 2030. Osteoanabolic agents, such as teriparatide and abaloparatide, are not only effective in reducing fracture incidence but also improve skelet...
The study is based on applying Artificial Neural Network (ANN) based machine learning and Response Surface Methodology (RSM) as simultaneous bivariate approaches in developing controlled-release rivaroxaban (RVX) osmotic tablets. The influence of dif...
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