Bilirubin biosensors for liver disease management.
Journal:
Clinica chimica acta; international journal of clinical chemistry
Published Date:
Sep 1, 2025
Abstract
Bilirubin is a vital biomarker that plays a significant role in assessing liver function and diagnosing hemolytic disorders. While current detection methods are indeed sufficient for clinical practice, the accurate and timely detection of bilirubin levels remains essential for effective management of liver diseases. Enhanced detection capabilities through sensitive nanoscale biosensors can provide more precise monitoring, which may lead to earlier identification of abnormalities and improved patient outcomes. Although the existing methods are adequate, the advancements in biosensor technology could facilitate more proactive management strategies for liver conditions, potentially allowing for timely interventions that are crucial in clinical settings. This paper explores novel biosensor approaches for the detection of bilirubin, emphasizing advancements in sensitivity, specificity, and real-time monitoring capabilities. We review various biosensor technologies, including electrochemical, optical, and piezoelectric methods, highlighting their mechanisms, advantages, and limitations. Recent innovations, such as nanomaterial integration and microfluidic systems, are discussed for their potential to enhance detection performance and reduce response times. Furthermore, we examine the application of machine learning algorithms in data interpretation to improve diagnostic accuracy. This comprehensive overview aims to provide insights into the future of bilirubin biosensing technologies, paving the way for improved patient outcomes in liver disease management and related conditions.
