PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability.

Journal: Journal of the American Medical Informatics Association : JAMIA
Published Date: Mar 28, 2016

Abstract

OBJECTIVE: Health care generated data have become an important source for clinical and genomic research. Often, investigators create and iteratively refine phenotype algorithms to achieve high positive predictive values (PPVs) or sensitivity, thereby identifying valid cases and controls. These algorithms achieve the greatest utility when validated and shared by multiple health care systems.Materials and Methods We report the current status and impact of the Phenotype KnowledgeBase (PheKB, http://phekb.org), an online environment supporting the workflow of building, sharing, and validating electronic phenotype algorithms. We analyze the most frequent components used in algorithms and their performance at authoring institutions and secondary implementation sites.

Authors

  • Jacqueline C Kirby
    Vanderbilt University Medical Center, Nashville, TN, USA.
  • Peter Speltz
    Vanderbilt University Medical Center, Nashville, TN, USA.
  • Luke V Rasmussen
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
  • Melissa Basford
    Vanderbilt University Medical Center, Nashville, TN, USA.
  • Omri Gottesman
    Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Peggy L Peissig
    Marshfield Clinic Research Foundation, Marshfield, WI, USA.
  • Jennifer A Pacheco
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
  • Gerard Tromp
    Geisinger Health System, Danville, PA, USA.
  • Jyotishman Pathak
    Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
  • David S Carrell
    Group Health Research Institute, Seattle, WA, 98101, USA.
  • Stephen B Ellis
    Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Todd Lingren
    Department of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Will K Thompson
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
  • Guergana Savova
    Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Jonathan Haines
    Case Western University, Cleveland, OH, USA.
  • Dan M Roden
    Vanderbilt University Medical Center, Nashville, TN, USA.
  • Paul A Harris
    Vanderbilt University Medical Center, Nashville, TN, USA.
  • Joshua C Denny
    Vanderbilt University, Nashville, TN.

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