Comparison of module detection algorithms in protein networks and investigation of the biological meaning of predicted modules.
Journal:
BMC bioinformatics
Published Date:
Mar 18, 2016
Abstract
BACKGROUND: It is generally acknowledged that a functional understanding of a biological system can only be obtained by an understanding of the collective of molecular interactions in form of biological networks. Protein networks are one particular network type of special importance, because proteins form the functional base units of every biological cell. On a mesoscopic level of protein networks, modules are of significant importance because these building blocks may be the next elementary functional level above individual proteins allowing to gain insight into fundamental organizational principles of biological cells.