Clinical phenotyping in selected national networks: demonstrating the need for high-throughput, portable, and computational methods.

Journal: Artificial intelligence in medicine
Published Date:

Abstract

OBJECTIVE: The combination of phenomic data from electronic health records (EHR) and clinical data repositories with dense biological data has enabled genomic and pharmacogenomic discovery, a first step toward precision medicine. Computational methods for the identification of clinical phenotypes from EHR data will advance our understanding of disease risk and drug response, and support the practice of precision medicine on a national scale.

Authors

  • Rachel L Richesson
    Duke University School of Nursing, 311 Trent Drive, Durham, NC 27710 USA. Electronic address: rachel.richesson@duke.edu.
  • Jimeng Sun
    College of Computing Georgia Institute of Technology Atlanta, GA, USA.
  • Jyotishman Pathak
    Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
  • Abel N Kho
    Northwestern University, Evanston, IL.
  • Joshua C Denny
    Vanderbilt University, Nashville, TN.