Diagnostic value of sleep stage dissociation as visualized on a 2-dimensional sleep state space in human narcolepsy.

Journal: Journal of neuroscience methods
PMID: 28219726

Abstract

BACKGROUND: Type 1 narcolepsy (NT1) is characterized by symptoms believed to represent Rapid Eye Movement (REM) sleep stage dissociations, occurrences where features of wake and REM sleep are intermingled, resulting in a mixed state. We hypothesized that sleep stage dissociations can be objectively detected through the analysis of nocturnal Polysomnography (PSG) data, and that those affecting REM sleep can be used as a diagnostic feature for narcolepsy.

Authors

  • Anders Vinther Olsen
    Center for Sleep Sciences and Medicine, Stanford School of Medicine, Palo Alto, CA, USA; Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark. Electronic address: Avo.blunt@gmail.com.
  • Jens Stephansen
    Center for Sleep Sciences and Medicine, Stanford School of Medicine, Palo Alto, CA, USA; Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Eileen Leary
    Center for Sleep Sciences and Medicine, Stanford School of Medicine, Palo Alto, CA, USA.
  • Paul E Peppard
    Department of Preventive medicine, U Madison Wisconsin Madison, Wisconsin, USA.
  • Hong Sheungshul
    Sleep Disorder Center, Catholic University, Seoul, South Korea.
  • Poul Jørgen Jennum
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Rigshospitalet, Denmark.
  • Helge Sorensen
    Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Emmanuel Mignot
    Center for Sleep Sciences and Medicine, Stanford School of Medicine, Palo Alto, CA, USA.

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