GENIUS: web server to predict local gene networks and key genes for biological functions.

Journal: Bioinformatics (Oxford, England)
Published Date: Mar 1, 2017

Abstract

SUMMARY: GENIUS is a user-friendly web server that uses a novel machine learning algorithm to infer functional gene networks focused on specific genes and experimental conditions that are relevant to biological functions of interest. These functions may have different levels of complexity, from specific biological processes to complex traits that involve several interacting processes. GENIUS also enriches the network with new genes related to the biological function of interest, with accuracies comparable to highly discriminative Support Vector Machine methods.

Authors

  • Tomas Puelma
    Millennium Nucleus Center for Plant Systems and Synthetic Biology, FONDAP Center for Genome Regulation, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
  • Viviana Araus
    Millennium Nucleus Center for Plant Systems and Synthetic Biology, FONDAP Center for Genome Regulation, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
  • Javier Canales
    Millennium Nucleus Center for Plant Systems and Synthetic Biology, FONDAP Center for Genome Regulation, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
  • Elena A Vidal
    Millennium Nucleus Center for Plant Systems and Synthetic Biology, FONDAP Center for Genome Regulation, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
  • Juan M Cabello
    Millennium Nucleus Center for Plant Systems and Synthetic Biology, FONDAP Center for Genome Regulation, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
  • Alvaro Soto
    Millennium Nucleus Center for Plant Systems and Synthetic Biology, Departamento de Ciencias de la Computación, Facultad de Ingeniería, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.
  • Rodrigo A Gutiérrez
    Millennium Nucleus Center for Plant Systems and Synthetic Biology, FONDAP Center for Genome Regulation, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.

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