Sequence based predictor for discrimination of enhancer and their types by applying general form of Chou's trinucleotide composition.
Journal:
Computer methods and programs in biomedicine
Published Date:
Jul 1, 2017
Abstract
BACKGROUND AND OBJECTIVES: Enhancers are pivotal DNA elements, which are widely used in eukaryotes for activation of transcription genes. On the basis of enhancer strength, they are further classified into two groups; strong enhancers and weak enhancers. Due to high availability of huge amount of DNA sequences, it is needed to develop fast, reliable and robust intelligent computational method, which not only identify enhancers but also determines their strength. Considerable progress has been achieved in this regard; however, timely and precisely identification of enhancers is still a challenging task.