Deep convolutional neural networks for classifying head and neck cancer using hyperspectral imaging.

Journal: Journal of biomedical optics
Published Date:

Abstract

Surgical cancer resection requires an accurate and timely diagnosis of the cancer margins in order to achieve successful patient remission. Hyperspectral imaging (HSI) has emerged as a useful, noncontact technique for acquiring spectral and optical properties of tissue. A convolutional neural network (CNN) classifier is developed to classify excised, squamous-cell carcinoma, thyroid cancer, and normal head and neck tissue samples using HSI. The CNN classification was validated by the manual annotation of a pathologist specialized in head and neck cancer. The preliminary results of 50 patients indicate the potential of HSI and deep learning for automatic tissue-labeling of surgical specimens of head and neck patients.

Authors

  • Martin Halicek
    Georgia Institute of Technology and Emory University, The Wallace H. Coulter Department of Biomedical Engineering, Atlanta, Georgia, United StatesbMedical College of Georgia, Augusta, Georgia, United States.
  • Guolan Lu
  • James V Little
    Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, United States.
  • Xu Wang
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907.
  • Mihir Patel
    Emory University School of Medicine, Department of Otolaryngology, Atlanta, Georgia, United StatesfWinship Cancer Institute of Emory University, Atlanta, Georgia, United States.
  • Christopher C Griffith
    Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, United States.
  • Mark W El-Deiry
    Emory University School of Medicine, Department of Otolaryngology, Atlanta, Georgia, United StatesfWinship Cancer Institute of Emory University, Atlanta, Georgia, United States.
  • Amy Y Chen
    Emory University School of Medicine, Department of Otolaryngology, Atlanta, Georgia, United StatesfWinship Cancer Institute of Emory University, Atlanta, Georgia, United States.
  • Baowei Fei