During radiotherapy, the radiation dose delivered to circulating blood can result in radiation-induced lymphopenia, which is correlated with adverse clinical outcomes like lower survival. Increasingly complex models to simulate radiation dose deliver...
Journal of cancer research and clinical oncology
Dec 20, 2025
PURPOSE: With increasing reliance on large language models (LLMs) for health information, this study evaluated reliability and quality, understandability, actionability, readability and misinformation risk of responses from LLMs to oral health concer...
Immune checkpoint inhibitors have partially improved treatment outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but the response rate remains low, with only a few patients benefiting. Mechanistically, HNSCC tumor cells often ...
. Accurate dose accumulation relies on deformable image registration (DIR) to track dose across multiple images. However, DIR introduces uncertainties that can impact cumulative dose distributions. In this study, we present a probabilistic framework ...
Biomedical physics & engineering express
Dec 8, 2025
. This study aims to synthesize CT from MR images for radiotherapy planning of head and neck tumor using an improved three-dimensional conditional generative adversarial network (3D cGAN) based on dual-attention modules.. A total of 212 paired CT and...
Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios. Traditional CB...
Biomedical physics & engineering express
Nov 25, 2025
The fidelity of dose distribution prediction is paramount for radiotherapy planning. While existing deep learning-based methods have obtained noteworthy performance, most of them pursue the accurate prediction of global dose distribution but neglect ...
BACKGROUND: HPV status is a key determinant of prognosis and treatment response in head and neck squamous cell carcinoma (HNSCC). To investigate how HPV influences the tumor-immune-stromal landscape, we performed high-dimensional spatial profiling, i...
Head and neck cancers represent a critical global health issue, contributing to substantial morbidity and mortality. Recent research has explored the role of microRNAs (miRNAs) in these cancers by constructing miRNA-associated disease networks using ...
BACKGROUND: For the effective treatment planning of head and neck cancers, precise tumor segmentation is vital. The combination of artificial intelligence (AI) technology with imaging systems like positron emission tomography (PET) and PET/ computed ...
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