Revealing protein functions based on relationships of interacting proteins and GO terms.

Journal: Journal of biomedical semantics
Published Date: Sep 20, 2017

Abstract

BACKGROUND: In recent years, numerous computational methods predicted protein function based on the protein-protein interaction (PPI) network. These methods supposed that two proteins share the same function if they interact with each other. However, it is reported by recent studies that the functions of two interacting proteins may be just related. It will mislead the prediction of protein function. Therefore, there is a need for investigating the functional relationship between interacting proteins.

Authors

  • Zhixia Teng
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
  • Maozu Guo
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
  • Xiaoyan Liu
    College of Information Technology, Jilin Agricultural University, Changchun, China.
  • Zhen Tian
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
  • Kai Che
    Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin, 150001, China.

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