Tafoxiparin, a novel drug candidate for cervical ripening and labor augmentation: results from 2 randomized, placebo-controlled studies.

Journal: American journal of obstetrics and gynecology
PMID: 38462256

Abstract

BACKGROUND: Slow progression of labor is a common obstetrical problem with multiple associated complications. Tafoxiparin is a depolymerized form of heparin with a molecular structure that eliminates the anticoagulant effects of heparin. We report on 2 phase II clinical studies of tafoxiparin in primiparas. Study 1 was an exploratory, first-in-pregnant-women study and study 2 was a dose-finding study.

Authors

  • Gunvor Ekman-Ordeberg
    Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden; Dilafor AB, Solna, Sweden. Electronic address: gunvor.ekman-ordeberg@ki.se.
  • Margareta Hellgren-Wångdahl
    Department of Obstetrics and Gynecology, Sahlgrenska Academy, Göteborg, Sweden.
  • Annika Jeppson
    Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Leena Rahkonen
    Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland.
  • Marie Blomberg
    Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Karin Pettersson
    Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
  • Carina Bejlum
    Department of Obstetrics and Gynecology, North Älvsborg County Hospital, Trollhättan, Sweden.
  • Malin Engberg
    Department of Obstetrics and Gynecology, Skaraborg Hospital, Skövde, Sweden.
  • Mette Ludvigsen
    Department of Obstetrics and Gynecology, Hvidovre Hospital, Hvidovre, Denmark.
  • Jukka Uotila
    Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.
  • Kati Tihtonen
    Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.
  • Gunilla Hallberg
    Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
  • Maria Jonsson
    Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

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