AIMC Topic: Heparin
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Anticoagulation colloidal microrobots based on heparin-mimicking polymers.
Journal of colloid and interface science
Mar 19, 2025
Coagulation within blood vessels is a major cause of cardiovascular disease and global mortality, highlighting the urgent need for effective anticoagulant strategies. In this study, we introduce a dynamic and highly efficient anticoagulant platform, ...
Heparin in sepsis: current clinical findings and possible mechanisms.
Frontiers in immunology
Dec 6, 2024
Sepsis is a clinical syndrome resulting from the interaction between coagulation, inflammation, immunity and other systems. Coagulation activation is an initial factor for sepsis to develop into multiple organ dysfunction. Therefore, anticoagulant th...
Tafoxiparin, a novel drug candidate for cervical ripening and labor augmentation: results from 2 randomized, placebo-controlled studies.
American journal of obstetrics and gynecology
May 17, 2023
BACKGROUND: Slow progression of labor is a common obstetrical problem with multiple associated complications. Tafoxiparin is a depolymerized form of heparin with a molecular structure that eliminates the anticoagulant effects of heparin. We report on...
Deep Survival Analysis With Clinical Variables for COVID-19.
IEEE journal of translational engineering in health and medicine
Mar 14, 2023
OBJECTIVE: Millions of people have been affected by coronavirus disease 2019 (COVID-19), which has caused millions of deaths around the world. Artificial intelligence (AI) plays an increasing role in all areas of patient care, including prognostics. ...
Systematic review of machine learning models for personalised dosing of heparin.
British journal of clinical pharmacology
May 14, 2021
AIM: To identify and critically appraise studies of prediction models, developed using machine learning (ML) methods, for determining the optimal dosing of unfractionated heparin (UFH).
Continuous Infusion Low-Dose Unfractionated Heparin for the Management of Hypercoagulability Associated With COVID-19.
Journal of pharmacy practice
Oct 14, 2020
INTRODUCTION: The Coronavirus Disease 2019 (COVID-19) is associated with severe hypercoagulability. There is currently limited evidence supporting the routine use of therapeutic anticoagulation in the setting of COVID-19.
Applying Machine Learning for Prescriptive Support: A Use Case with Unfractionated Heparin in Intensive Care Units.
Studies in health technology and informatics
Aug 22, 2024
Continuous unfractionated heparin is widely used in intensive care, yet its complex pharmacokinetic properties complicate the determination of appropriate doses. To address this challenge, we developed machine learning models to predict over- and und...
[Determination of sulfation degree of heparin and low molecular weight heparins by capillary electrophoresis].
Se pu = Chinese journal of chromatography
Oct 8, 2020
Heparin is composed of a highly sulfated linear saccharide and is widely used as an anticoagulant. Low molecular weight heparins (LMWHs) are derived from the unfractionated heparin (UFH) by enzymatic or chemical degradation. LMWHs have largely replac...
Fabrication, Characterization, and Hemocompatibility Investigation of Polysulfone Grafted With Polyethylene Glycol and Heparin Used in Membrane Oxygenators.
Artificial organs
Nov 1, 2016
Polysulfone (PSF) was grafted chemically with polyethylene glycol (PEG) of different molecular weights (400, 2000, 10 000, and 20 000) and heparin to prepare PSF-PEG-Hep membranes (labeled as PSF-PEG400-Hep, PSF-PEG2000-Hep, PSF-PEG10 000-Hep, and PS...
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