Combining Biomarkers with EMR Data to Identify Patients in Different Phases of Sepsis.

Journal: Scientific reports
Published Date: Sep 7, 2017

Abstract

Sepsis is a leading cause of death and is the most expensive condition to treat in U.S. hospitals. Despite targeted efforts to automate earlier detection of sepsis, current techniques rely exclusively on using either standard clinical data or novel biomarker measurements. In this study, we apply machine learning techniques to assess the predictive power of combining multiple biomarker measurements from a single blood sample with electronic medical record data (EMR) for the identification of patients in the early to peak phase of sepsis in a large community hospital setting. Combining biomarkers and EMR data achieved an area under the receiver operating characteristic (ROC) curve (AUC) of 0.81, while EMR data alone achieved an AUC of 0.75. Furthermore, a single measurement of six biomarkers (IL-6, nCD64, IL-1ra, PCT, MCP1, and G-CSF) yielded the same predictive power as collecting an additional 16 hours of EMR data(AUC of 0.80), suggesting that the biomarkers may be useful for identifying these patients earlier. Ultimately, supervised learning using a subset of biomarker and EMR data as features may be capable of identifying patients in the early to peak phase of sepsis in a diverse population and may provide a tool for more timely identification and intervention.

Authors

  • Ishan Taneja
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Bobby Reddy
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Gregory Damhorst
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Sihai Dave Zhao
    Department of Statistics, University of Illinois at Urbana Champaign, Illini Hall, 725S Wright St #101, 61820, Champaign, IL, USA.
  • Umer Hassan
    Department of Electrical and Computer Engineering, School of Engineering, Rutgers, The State University of New Jersey Piscataway NJ 08854 USA umer.hassan@rutgers.edu +1-848-445-2164.
  • Zachary Price
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Tor Jensen
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Tanmay Ghonge
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Manish Patel
    The University of Texas Health Science Center at Houston-Center for Advanced Heart Failure, Houston, TX, USA.
  • Samuel Wachspress
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Jackson Winter
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Michael Rappleye
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Gillian Smith
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Ryan Healey
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA.
  • Muhammad Ajmal
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • Muhammad Khan
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • Jay Patel
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.
  • Harsh Rawal
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • Raiya Sarwar
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • Sumeet Soni
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • Syed Anwaruddin
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • Benjamin Davis
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • James Kumar
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • Karen White
    Biomedical Research Center, Carle Foundation Hospital, 61801, Urbana, IL, USA.
  • Rashid Bashir
    Department of Bioengineering, University of Illinois at Urbana Champaign, 1270 Digital Computer Laboratory, 1304W, Springfield Ave., 61801, Urbana, IL, USA. rbashir@illinois.edu.
  • Ruoqing Zhu
    Department of Statistics, University of Illinois at Urbana Champaign, Illini Hall, 725S Wright St #101, 61820, Champaign, IL, USA. rqzhu@illinois.edu.

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