Machine Learning-Based Gene Prioritization Identifies Novel Candidate Risk Genes for Inflammatory Bowel Disease.

Journal: Inflammatory bowel diseases
Published Date:

Abstract

BACKGROUND: The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders, associated with genetic, immunologic, and environmental factors. Although hundreds of genes are implicated in IBD etiology, it is likely that additional genes play a role in the disease process. We developed a machine learning-based gene prioritization method to identify novel IBD-risk genes.

Authors

  • Ofer Isakov
    *Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; †Department of Gastroenterology and Liver Diseases, IBD Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; and ‡Genetic Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Iris Dotan
  • Shay Ben-Shachar