AIMC Topic: Databases, Genetic

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Identification of cell senescence-related genes in spontaneous preterm birth based on bioinformatics analysis and machine learning.

PloS one
Spontaneous premature birth (SPTB) is a common pregnancy complication; however, few studies have explored cell senescence-related markers in SPTB. Bioinformatics and machine learning approaches were used to predict potential biomarkers associated wit...

GermVersity: A free and user-friendly interface to enhance the visualization and analysis of genebank data.

PloS one
Genebanks are crucial for food security and industrial applications. However, their heterogeneous nature hinders effective utilization. To address this, the GermVersity platform was developed to integrate conventional, artificial intelligence, and da...

Deciphering the clinical implication of an obesity-related gene signature as the novel biomarker for acute myocardial infarction diagnosis.

Scientific reports
Acute myocardial infarction (AMI) stands as a major contributor to mortality and disability worldwide, with obesity playing a significant role in its development. This study aims to investigate potential biomarkers associated with obesity-related gen...

Exploring shared diagnostic genes and molecular mechanisms in multiple sclerosis and psoriasis through bioinformatics analysis and machine learning.

Biochemical and biophysical research communications
BACKGROUND: Multiple sclerosis (MS) and psoriasis are both immune-mediated inflammatory diseases. Previous studies have reported comorbidity between MS and psoriasis, but the underlying mechanisms remain unclear. This study aims to elucidate the shar...

TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation.

Molecular medicine reports
Psoriasis is a systemic immune‑mediated skin disease, typically considered to be incurable. Identification of meaningful biomarkers has been a notable challenge in psoriasis prevention and management. The present study aimed to determine the signatur...

Comparative assessment of annotation tools reveals critical antimicrobial resistance knowledge gaps in Klebsiella pneumoniae.

Scientific reports
Bacterial antimicrobial resistance (AMR) poses a significant public health threat. The increase of both global awareness and affordable whole genome sequencing has yielded an ever-growing collection of bacterial genome sequence datasets and correspon...

Machine learning-based screening and validation of pyroptosis-associated prognostic genes and potential drugs in cervical cancer.

BMC medical genomics
Pyroptosis is a newly discovered form of programmed cell death, but its mechanism in the development of cervical cancer has not been elucidated. Cervical cancer differentially expressed pyroptosis-related genes were identified via bioinformatic analy...

Identification of potential biomarkers for Lyme disease using bioinformatics and machine learning.

Clinical and experimental medicine
Lyme disease (LD) presents significant diagnostic challenges due to the absence of a reliable screening method for initial detection. This study aimed to identify potential biomarkers using bioinformatics and machine learning algorithms, which may co...

Natural language processing of gene descriptions for overrepresentation analysis with GeneTEA.

Genome biology
Overrepresentation analysis is used to identify biological enrichment in a list of genes. Here, we introduce GeneTEA, a model that ingests free-text gene descriptions and incorporates natural language processing methods to learn a sparse gene-by-term...

Identification of coagulation-related biomarkers in osteoarthritis and immune infiltration analysis based on bioinformatics.

Hereditas
BACKGROUND: Osteoarthritis (OA) is a common degenerative disorder characterized primarily by articular cartilage degradation and chronic inflammation. Although direct evidence elucidating the specific mechanisms underlying the coagulation-immune axis...