Reconstructing cancer drug response networks using multitask learning.

Journal: BMC systems biology
Published Date: Oct 10, 2017

Abstract

BACKGROUND: Translating in vitro results to clinical tests is a major challenge in systems biology. Here we present a new Multi-Task learning framework which integrates thousands of cell line expression experiments to reconstruct drug specific response networks in cancer.

Authors

  • Matthew Ruffalo
    Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA 15213.
  • Petar Stojanov
    Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
  • Venkata Krishna Pillutla
    Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
  • Rohan Varma
    Electrical and Computer Engineering, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
  • Ziv Bar-Joseph
    Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA 15213.

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