BACKGROUND: Data on neoadjuvant treatment with trastuzumab biosimilars, particularly CT-P6, in combination with pertuzumab, are limited. This study evaluates the efficacy, tolerability, and immunogenicity of CT-P6 plus pertuzumab and chemotherapy, in...
OBJECTIVE: This study aims to both develop and evaluate a predictive model for ureteral access sheath(UAS)placement success using preoperative CT-based 3D ureteral imaging and machine learning techniques. Specifically, it investigates the impact of u...
Six months of drug treatment is standard of care for drug-sensitive pulmonary tuberculosis (TB). Understanding the factors determining the length of treatment required for durable cure would allow individualization of treatment durations. We conducte...
Following uveal melanoma (UM) affected treatment using ruthenium-106 brachytherapy, tumor thickness patterns fall into one of four categories: decrease (regression), increase (recurrence), stop (stable), or other, which are assessed in follow-up A-mo...
Discontinuation of denosumab is associated with a rebound increase in osteoporotic fracture (OF) risk, and bisphosphonates (BPs) are commonly recommended as sequential therapy to mitigate this risk. However, their real-world effectiveness-and whether...
BACKGROUND: The development of immunotherapy has provided new hope for patients with advanced gastric cancer (AGC). However, due to the high heterogeneity of the disease, the efficacy of first-line immunochemotherapy varies among patients. There is s...
PURPOSE: To develop a machine learning model for predicting stone-free (SF) outcomes following extracorporeal shock wave lithotripsy (SWL) and to identify key clinical and stone-related predictors using interpretable machine learning techniques.
BACKGROUND: Machine learning (ML) models show promise in predicting post-traumatic stress disorder (PTSD) treatment outcomes, but it is unknown how their predictions compare to those of clinicians. This study directly compared the accuracy of clinici...
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a growing global health challenge. Conventional diagnostic tools have limited sensitivity and specificity for early-stage disease. In this context, long non-coding RNAs (lncRNAs) have emerged as promisin...
Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with serious long-term effects if untreated, emphasizing the need for early treatment given its neurobiological heterogeneity. This study introduces a novel expla...
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