Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer.

Journal: JAMA
Published Date:

Abstract

IMPORTANCE: Application of deep learning algorithms to whole-slide pathology images can potentially improve diagnostic accuracy and efficiency.

Authors

  • Babak Ehteshami Bejnordi
    Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Mitko Veta
    Medical Image Analysis Group, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • Paul Johannes van Diest
    Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Bram van Ginneken
    Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Fraunhofer Mevis, Bremen, Germany.
  • Nico Karssemeijer
  • Geert Litjens
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Jeroen A W M van der Laak
    Diagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Meyke Hermsen
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Quirine F Manson
    Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Maschenka Balkenhol
    Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Oscar Geessink
    Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Nikolaos Stathonikos
    Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Marcory Crf van Dijk
    Rijnstate Hospital, Arnhem, the Netherlands.
  • Peter Bult
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Francisco Beca
    BeckLab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  • Andrew H Beck
  • Dayong Wang
    BeckLab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  • Aditya Khosla
    Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA.
  • Rishab Gargeya
    The Harker School, San Jose, California.
  • Humayun Irshad
    BeckLab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  • Aoxiao Zhong
    Center for Clinical Data Science, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Qi Dou
  • Quanzheng Li
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
  • Hao Chen
    The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
  • Huang-Jing Lin
    Chinese University of Hong Kong, Hong Kong, China.
  • Pheng-Ann Heng
  • Christian Haß
    ExB Research and Development GmbH, Munich, Germany.
  • Elia Bruni
    ExB Research and Development GmbH, Munich, Germany.
  • Quincy Wong
    Munich Business School, Munich, Germany.
  • Ugur Halici
  • Mustafa Ümit Öner
    Department of Electrical and Electronics Engineering, Middle East Technical University, Ankara, Turkey.
  • Rengul Cetin-Atalay
    CanSyL, Graduate School of Informatics, Middle East Technical University, Ankara, 06800, Turkey.
  • Matt Berseth
    NLP LOGIX, Jacksonville, Florida.
  • Vitali Khvatkov
    Smart Imaging Technologies, Houston, Texas.
  • Alexei Vylegzhanin
    Smart Imaging Technologies, Houston, Texas.
  • Oren Kraus
    Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Muhammad Shaban
    Tissue Image Analytics Lab, Department of Computer Science, University of Warwick, Coventry, United Kingdom.
  • Nasir Rajpoot
    Department of Computer Science, University of Warwick, Coventry, UK.
  • Ruqayya Awan
    Department of Computer Science and Engineering, Qatar University, Doha, Qatar.
  • Korsuk Sirinukunwattana
  • Talha Qaiser
    Tissue Image Analytics Lab, Department of Computer Science, University of Warwick, Coventry, United Kingdom.
  • Yee-Wah Tsang
    Department of Pathology, University Hospitals Coventry and Warwickshire National Health Service Foundation Trust, Coventry, United Kingdom.
  • David Tellez
    Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Jonas Annuscheit
    Hochschule für Technik und Wirtschaft, Berlin, Germany.
  • Peter Hufnagl
    Department of Digital Pathology and IT, Institute of Pathology, Charité University Hospital, Berlin, Germany.
  • Mira Valkonen
    BioMediTech and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Kimmo Kartasalo
    BioMediTech and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Leena Latonen
    BioMediTech and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Pekka Ruusuvuori
    BioMediTech and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Kaisa Liimatainen
    BioMediTech and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Shadi Albarqouni
  • Bharti Mungal
    Technical University of Munich, Munich, Germany.
  • Ami George
    Technical University of Munich, Munich, Germany.
  • Stefanie Demirci
  • Nassir Navab
    Chair for Computer Aided Medical Procedures & Augmented Reality, TUM School of Computation, Information and Technology, Technical University of Munich, Munich, Germany.
  • Seiryo Watanabe
    Department of Bioinformatic Engineering, Osaka University.
  • Shigeto Seno
    Department of Bioinformatic Engineering, Osaka University.
  • Yoichi Takenaka
    Department of Bioinformatic Engineering, Osaka University.
  • Hideo Matsuda
    Department of Bioinformatic Engineering, Osaka University.
  • Hady Ahmady Phoulady
    University of South Florida, Tampa, Florida.
  • Vassili Kovalev
    Biomedical Image Analysis Department, United Institute of Informatics Problems, Belarus National Academy of Sciences, Minsk, Belarus.
  • Alexander Kalinovsky
    Biomedical Image Analysis Department, United Institute of Informatics Problems, Belarus National Academy of Sciences, Minsk, Belarus.
  • Vitali Liauchuk
    Biomedical Image Analysis Department, United Institute of Informatics Problems, Belarus National Academy of Sciences, Minsk, Belarus.
  • Gloria Bueno
    VISILAB Group, ETSI Industriales, University of Castilla-La Mancha, Ciudad Real, Spain.
  • M Milagro Fernandez-Carrobles
    Visilab, University of Castilla-La Mancha, Ciudad Real, Spain.
  • Ismael Serrano
    Visilab, University of Castilla-La Mancha, Ciudad Real, Spain.
  • Oscar Deniz
    VISILAB Group, ETSI Industriales, University of Castilla-La Mancha, Ciudad Real, Spain.
  • Daniel Racoceanu
    Sorbonne University, Paris, France; Pontifical Catholic University of Peru, Lima, Peru. Electronic address: daniraco@gmail.com.
  • Rui Venâncio
    Sorbonne University, Pierre and Marie Curie University, Paris, France.