Extracting chemical-protein relations with ensembles of SVM and deep learning models.

Journal: Database : the journal of biological databases and curation
Published Date:

Abstract

Mining relations between chemicals and proteins from the biomedical literature is an increasingly important task. The CHEMPROT track at BioCreative VI aims to promote the development and evaluation of systems that can automatically detect the chemical-protein relations in running text (PubMed abstracts). This work describes our CHEMPROT track entry, which is an ensemble of three systems, including a support vector machine, a convolutional neural network, and a recurrent neural network. Their output is combined using majority voting or stacking for final predictions. Our CHEMPROT system obtained 0.7266 in precision and 0.5735 in recall for an F-score of 0.6410 during the challenge, demonstrating the effectiveness of machine learning-based approaches for automatic relation extraction from biomedical literature and achieving the highest performance in the task during the 2017 challenge.Database URL: http://www.biocreative.org/tasks/biocreative-vi/track-5/.

Authors

  • Yifan Peng
    Department of Population Health Sciences, Weill Cornell Medicine, New York, USA.
  • Anthony Rios
    Department of Computer Science, University of Kentucky, 329 Rose Street, Lexington, KY 40506, USA. Electronic address: anthony.rios1@uky.edu.
  • Ramakanth Kavuluru
    Div. of Biomedical Informatics, Dept. of Internal Medicine, Dept. of Computer Science, University of Kentucky, Lexington, KY.
  • Zhiyong Lu
    National Center for Biotechnology Information, Bethesda, MD 20894 USA.