Machine Learning Algorithm Predicts Cardiac Resynchronization Therapy Outcomes: Lessons From the COMPANION Trial.

Journal: Circulation. Arrhythmia and electrophysiology
PMID:

Abstract

BACKGROUND: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in heart failure patients with reduced left ventricular function and intraventricular conduction delay. However, individual outcomes vary significantly. This study sought to use a machine learning algorithm to develop a model to predict outcomes after CRT.

Authors

  • Matthew M Kalscheur
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison. mmkalsch@medicine.wisc.edu.
  • Ryan T Kipp
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison.
  • Matthew C Tattersall
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison.
  • Chaoqun Mei
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison.
  • Kevin A Buhr
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison.
  • David L DeMets
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison.
  • Michael E Field
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison.
  • Lee L Eckhardt
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison.
  • C David Page
    From the Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health (M.M.K., R.T.K., M.C.T., M.E.F., L.L.E.), Department of Biostatistics and Medical Informatics (C.M., K.A.B., D.L.D., C.D.P.), University of Wisconsin Institute for Clinical and Translational Research (C.M.), and Department of Computer Sciences (C.D.P.), University of Wisconsin-Madison.