Prediction of Drug-Plasma Protein Binding Using Artificial Intelligence Based Algorithms.

Journal: Combinatorial chemistry & high throughput screening
Published Date: Jan 1, 2018

Abstract

AIM AND OBJECTIVE: Plasma protein binding (PPB) has vital importance in the characterization of drug distribution in the systemic circulation. Unfavorable PPB can pose a negative effect on clinical development of promising drug candidates. The drug distribution properties should be considered at the initial phases of the drug design and development. Therefore, PPB prediction models are receiving an increased attention.

Authors

  • Rajnish Kumar
    Department of Medical Laboratory Technology, School of Allied Health Sciences, Delhi Pharmaceutical Sciences and Research University, Delhi 110017, India.
  • Anju Sharma
    Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, 226028, Uttar Pradesh. India.
  • Mohammed Haris Siddiqui
    Department of Bioengineering, Integral University, Dasauli, P.O. Basha, Kursi Road, Lucknow, Uttar Pradesh. India.
  • Rajesh Kumar Tiwari
    Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, 226028, Uttar Pradesh. India.

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