AIMC Topic: Blood Proteins
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A longitudinal cohort study uncovers plasma protein biomarkers predating clinical onset and treatment response of rheumatoid arthritis.
Nature communications
Jul 21, 2025
Rheumatoid arthritis (RA) is a systemic inflammatory condition posing challenges in identifying biomarkers for onset, severity and treatment responses. Here we investigate the plasma proteome in a longitudinal cohort of 278 RA patients, alongside 60 ...
Plasma proteomics for biomarker discovery in childhood tuberculosis.
Nature communications
Jul 19, 2025
Failure to rapidly diagnose tuberculosis disease (TB) and initiate treatment is a driving factor of TB as a leading cause of death in children. Current TB diagnostic assays have poor performance in children, thus a global priority is the identificati...
A novel UHPLC-HRMS method for simultaneous determination of 20 amino metabolites and proteins in lymphoma patients' cells and serum.
Scientific reports
Jul 1, 2025
Highly sensitive and selective monitoring of amino metabolites such as glutamine, arginine, tryptophan and related proteins played significant roles in early diagnosis and warning of lymphoma. But those limited abundance and lacked chromophore group ...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.
Nature communications
Jul 1, 2025
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Identification of plasma proteins associated with seizures in epilepsy: A consensus machine learning approach.
PloS one
Jul 1, 2025
Blood-based biomarkers in epilepsy could constitute important research tools advancing neurobiological understanding and valuable clinical tools for better diagnosis and follow-up. An interesting question is whether biomarker patterns could contribut...
A correlational study of plasma galectin-3 as a potential predictive marker of postoperative delirium in patients with acute aortic dissection.
Scientific reports
May 8, 2025
This study aimed to demonstrate whether plasma galectin-3 could predict the development of postoperative delirium (POD) in patients with acute aortic dissection (AAD). Prospective, observational study. Cardiac surgery intensive care unit. Consecutive...
Plasma Proteomic Profiles Predict Individual Future Osteoarthritis Risk.
Arthritis & rheumatology (Hoboken, N.J.)
Mar 20, 2025
OBJECTIVE: Osteoarthritis (OA) is a widespread degenerative joint disease that causes a considerable socioeconomic burden. Despite progress in genetic and environmental insights, early diagnosis is still limited by the lack of evident symptoms during...
Machine learning approach on plasma proteomics identifies signatures associated with obesity in the KORA FF4 cohort.
Diabetes, obesity & metabolism
Feb 27, 2025
AIMS: This study investigated the role of plasma proteins in obesity to identify predictive biomarkers and explore underlying biological mechanisms.
Quantitative abnormalities in the β-region of the electrophoretic profile of serum proteins as predictive markers of monoclonality: Machine learning for monoclonality prediction.
Clinical biochemistry
Feb 1, 2025
OBJECTIVE OF THE STUDY: To develop a machine learning algorithm aimed at predicting the presence of a monoclonal (M-) protein when the β-globulin fraction is elevated.
Machine learning models for predicting interaction affinity energy between human serum proteins and hemodialysis membrane materials.
Scientific reports
Jan 28, 2025
Membrane incompatibility poses significant health risks, including severe complications and potential fatality. Surface modification of membranes has emerged as a pivotal technology in the membrane industry, aiming to improve the hemocompatibility an...
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