Mapping Patient Trajectories using Longitudinal Extraction and Deep Learning in the MIMIC-III Critical Care Database.

Journal: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Published Date:

Abstract

Electronic Health Records (EHRs) contain a wealth of patient data useful to biomedical researchers. At present, both the extraction of data and methods for analyses are frequently designed to work with a single snapshot of a patient's record. Health care providers often perform and record actions in small batches over time. By extracting these care events, a sequence can be formed providing a trajectory for a patient's interactions with the health care system. These care events also offer a basic heuristic for the level of attention a patient receives from health care providers. We show that is possible to learn meaningful embeddings from these care events using two deep learning techniques, unsupervised autoencoders and long short-term memory networks. We compare these methods to traditional machine learning methods which require a point in time snapshot to be extracted from an EHR.

Authors

  • Brett K Beaulieu-Jones
    Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, United States; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, United States. Electronic address: brettbe@med.upenn.edu.
  • Patryk Orzechowski
  • Jason H Moore
    University of Pennsylvania, Philadelphia, PA, USA.