Viral load kinetics and the clinical consequences of cytomegalovirus in kidney transplantation.

Journal: Frontiers in immunology
PMID: 38361528

Abstract

BACKGROUND: Despite advances in clinical management, cytomegalovirus (CMV) infection remains a serious complication and an important cause of morbidity and mortality following kidney transplantation. Here, we explore the importance of viral load kinetics as predictors of risk and potential guides to therapy to reduce transplant failure in a large longitudinal Genome Canada Transplant Consortium (GCTC) kidney transplant cohort.

Authors

  • Sabina Dobrer
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Karen R Sherwood
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Ishan Hirji
    Global Evidence and Outcomes, Takeda Development Center Americas, Inc., Lexington, MA, United States.
  • James Lan
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • John Gill
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Nancy Matic
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Paul A Keown
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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