AIMC Topic: Viral Load
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Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes.
Parasites & vectors
May 12, 2025
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumatic disease. The recently approved CHIKV vaccine, IXCHIQ, is based on a live-attenuated CHIKV strain ...
Challenges on the implementation of wastewater-based epidemiology as a prediction tool: the paradigm of SARS-CoV-2.
The Science of the total environment
May 6, 2025
Wastewater Based Epidemiology (WBE) has been identified as a tool for monitoring and predicting patterns of SARS-CoV-2 in communities. Several factors may lead to a day-to-day variation in the measurement of viral genetic material. Wastewater samples...
Plasma Epstein-Barr Virus DNA load for diagnostic and prognostic assessment in intestinal Epstein-Barr Virus infection.
Frontiers in cellular and infection microbiology
Jan 7, 2025
BACKGROUND: The prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure of intestinal EBV infection remains unexplored. This study aims to identify ideal threshold levels for plasma EBV DNA loads in the diagnosis ...
[Incidence and determinants of viral load rebound in people receiving multi-month dispensing of antiretroviral therapy at the Regional Annex Hospital of Dschang from 2018-2023].
The Pan African medical journal
Nov 12, 2024
INTRODUCTION: in Cameroon, multi-month dispensing (MMD) of antiretrovirals (ARVs) was introduced to improve treatment adherence among people living with HIV (PLHIV). However, this strategy has limitations that may lead to viral load rebound. The purp...
Prevention of adverse HIV treatment outcomes: machine learning to enable proactive support of people at risk of HIV care disengagement in Tanzania.
BMJ open
Sep 24, 2024
OBJECTIVES: This study aimed to develop a machine learning (ML) model to predict disengagement from HIV care, high viral load or death among people living with HIV (PLHIV) with the goal of enabling proactive support interventions in Tanzania. The alg...
Development, Validation, and Implementation of an Augmented Multiwell, Multitarget Quantitative PCR for the Analysis of Human Papillomavirus Genotyping through Software Automation, Data Science, and Artificial Intelligence.
The Journal of molecular diagnostics : JMD
Jul 5, 2024
The value of human papillomavirus (HPV) testing for cervical cancer screening is well established; however, its use as a primary screening option or as a reflex test after atypical cytology results is now gaining wider acceptance. The importance of f...
Viral load kinetics and the clinical consequences of cytomegalovirus in kidney transplantation.
Frontiers in immunology
Jan 31, 2024
BACKGROUND: Despite advances in clinical management, cytomegalovirus (CMV) infection remains a serious complication and an important cause of morbidity and mortality following kidney transplantation. Here, we explore the importance of viral load kine...
Different features identified by machine learning associated with the HIV compartmentalization in semen.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Jan 23, 2022
Genetic compartmentalization in semen has been observed in previous studies. However, genetic signatures associated with compartmentalization in semen are only beginning to be explored. A total of 2071 partial HIV env sequences for paired blood and s...
Rilpivirine plus cobicistat-boosted darunavir as alternative to standard three-drug therapy in HIV-infected, virologically suppressed subjects: Final results of the PROBE 2 trial.
Antiviral therapy
Oct 27, 2021
BACKGROUND: Primary analysis at 24 weeks showed that switching to rilpivirine plus darunavir/cobicistat was non-inferior to continuing a standard three-drug antiretroviral regimen in virologically suppressed people with HIV. We present efficacy and s...
Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2.
Viruses
Apr 2, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19 and is responsible for the ongoing pandemic. Screening of potential antiviral drugs against SARS-CoV-2 depend on in vitro experiments, which are based on the quantification ...
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