AIMC Topic: Cytomegalovirus Infections

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Enhancing the Predictions of Cytomegalovirus Infection in Severe Ulcerative Colitis Using a Deep Learning Ensemble Model: Development and Validation Study.

JMIR medical informatics
BACKGROUND: Cytomegalovirus (CMV) reactivation in patients with severe ulcerative colitis (UC) leads to worse outcomes; yet, early detection remains challenging due to the reliance on time-intensive biopsy procedures.

Estimation of Ganciclovir Exposure in Adults Transplant Patients by Machine Learning.

The AAPS journal
INTRODUCTION: Valganciclovir, a prodrug of ganciclovir (GCV), is used to prevent cytomegalovirus infection after transplantation, with doses adjusted based on creatinine clearance (CrCL) to target GCV AUC0-24 h of 40-60 mg*h/L. This sometimes leads t...

Application of machine-learning models to predict the ganciclovir and valganciclovir exposure in children using a limited sampling strategy.

Antimicrobial agents and chemotherapy
Intravenous ganciclovir and oral valganciclovir display significant variability in ganciclovir pharmacokinetics, particularly in children. Therapeutic drug monitoring currently relies on the area under the concentration-time (AUC). Machine-learning (...

Viral load kinetics and the clinical consequences of cytomegalovirus in kidney transplantation.

Frontiers in immunology
BACKGROUND: Despite advances in clinical management, cytomegalovirus (CMV) infection remains a serious complication and an important cause of morbidity and mortality following kidney transplantation. Here, we explore the importance of viral load kine...

Applying T-classifier, binary classifiers, upon high-throughput TCR sequencing output to identify cytomegalovirus exposure history.

Scientific reports
With the continuous development of information technology and the running speed of computers, the development of informatization has led to the generation of increasingly more medical data. Solving unmet needs such as employing the constantly develop...

A robust and interpretable end-to-end deep learning model for cytometry data.

Proceedings of the National Academy of Sciences of the United States of America
Cytometry technologies are essential tools for immunology research, providing high-throughput measurements of the immune cells at the single-cell level. Existing approaches in interpreting and using cytometry measurements include manual or automated ...

Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data.

PloS one
Chemogenomic approaches involving highly annotated compound sets and cell based high throughput screening are emerging as a means to identify novel drug targets. We have previously screened a collection of highly characterized kinase inhibitors (Khan...

Predictive factors of spontaneous CMV DNAemia clearance in kidney transplantation.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
UNLABELLED: Cytomegalovirus (CMV) infection occurs frequently after solid organ transplantation. Therapeutic strategies, in particular when to start a curative treatment, has not yet been defined. The purpose of this study was to assess predictive fa...

Sensitive detection of rare disease-associated cell subsets via representation learning.

Nature communications
Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to de...