Supporting shared hypothesis testing in the biomedical domain.

Journal: Journal of biomedical semantics
Published Date: Feb 8, 2018

Abstract

BACKGROUND: Pathogenesis of inflammatory diseases can be tracked by studying the causality relationships among the factors contributing to its development. We could, for instance, hypothesize on the connections of the pathogenesis outcomes to the observed conditions. And to prove such causal hypotheses we would need to have the full understanding of the causal relationships, and we would have to provide all the necessary evidences to support our claims. In practice, however, we might not possess all the background knowledge on the causality relationships, and we might be unable to collect all the evidence to prove our hypotheses.

Authors

  • Asan Agibetov
    Italian National Research Council, Via De Marini 6, Genoa, 16149, Italy.
  • Ernesto Jiménez-Ruiz
    Department of Informatics, University of Oslo, Oslo, Norway.
  • Marta Ondrésik
    3B's Research Group, Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Caldas das Taipas, Portugal.
  • Alessandro Solimando
    University of Genoa, Genoa, Italy.
  • Imon Banerjee
    Mayo Clinic, Department of Radiology, Scottsdale, AZ, USA.
  • Giovanna Guerrini
    University of Genoa, Genoa, Italy. giovanna.guerrini@unige.it.
  • Chiara E Catalano
    Italian National Research Council, Via De Marini 6, Genoa, 16149, Italy.
  • Joaquim M Oliveira
    3B's Research Group, Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal. Electronic address: miguel.oliveira@i3bs.uminho.pt.
  • Giuseppe Patanè
    Italian National Research Council, Via De Marini 6, Genoa, 16149, Italy.
  • Rui L Reis
    3B's Research Group, Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal.
  • Michela Spagnuolo
    Italian National Research Council, Via De Marini 6, Genoa, 16149, Italy.

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