Machine learning annotation of human branchpoints.

Journal: Bioinformatics (Oxford, England)
Published Date: Mar 15, 2018

Abstract

MOTIVATION: The branchpoint element is required for the first lariat-forming reaction in splicing. However current catalogues of human branchpoints remain incomplete due to the difficulty in experimentally identifying these splicing elements. To address this limitation, we have developed a machine-learning algorithm-branchpointer-to identify branchpoint elements solely from gene annotations and genomic sequence.

Authors

  • Bethany Signal
    Genomics and Epigenetics, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
  • Brian S Gloss
    Genomics and Epigenetics, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
  • Marcel E Dinger
    Genomics and Epigenetics, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
  • Tim R Mercer
    Genomics and Epigenetics, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

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