Exploiting semantic patterns over biomedical knowledge graphs for predicting treatment and causative relations.

Journal: Journal of biomedical informatics
Published Date:

Abstract

BACKGROUND: Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying different causal relations between biomedical entities is also critical to understand biomedical processes. Generally, natural language processing (NLP) and machine learning are used to predict specific relations between any given pair of entities using the distant supervision approach.

Authors

  • Gokhan Bakal
    Department of Computer Science, University of Kentucky, United States. Electronic address: mgokhanbakal@uky.edu.
  • Preetham Talari
    Division of Hospital Medicine, Department of Internal Medicine, University of Kentucky, United States. Electronic address: preetham.talari@uky.edu.
  • Elijah V Kakani
    Division of Hospital Medicine, Department of Internal Medicine, University of Kentucky, United States. Electronic address: elijah.kakani@uky.edu.
  • Ramakanth Kavuluru
    Div. of Biomedical Informatics, Dept. of Internal Medicine, Dept. of Computer Science, University of Kentucky, Lexington, KY.