Disease Specific Ontology of Adverse Events: Ontology extension and adaptation for Chronic Kidney Disease.
Journal:
Computers in biology and medicine
Published Date:
Aug 28, 2018
Abstract
BACKGROUND: Adverse Event (AE) ontology can be used to support interoperability and computer-assisted reasoning of AEs. Despite significant progress in developing biomedical ontologies, they are facing the obstacle of adoption partly because those ontologies are too general to meet the requirements of a specific domain. Understanding and representing of AEs for a specific domain such as Chronic Kidney Disease (CKD) has both theoretical and clinical significance. CKD patients are at a high risk for an array of disease-intervention specific AEs, and these in turn can contribute to disease progression unlike other diseases. This study proposes Disease Specific Ontology of Adverse Events (DSOAE) to address specific requirements of CKD, and applies it to different usage scenarios with real data.