Model based on GA and DNN for prediction of mRNA-Smad7 expression regulated by miRNAs in breast cancer.

Journal: Theoretical biology & medical modelling
Published Date: Dec 29, 2018

Abstract

BACKGROUND: The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. miRNAs regulate proteins expressions by arresting or degrading the mRNAs. The purpose of this work is to identify a miRNAs profile that regulates the expression of the mRNA coding for Smad7 in breast cancer using the data from patients with breast cancer obtained from the Cancer Genome Atlas Project.

Authors

  • Edgar Manzanarez-Ozuna
    Universidad Autónoma de Baja California, Carretera Transpeninsular Ensenada-Tijuana 3917 Colonia Playitas, C.P. 22860, Ensenada, B.C., Mexico.
  • Dora-Luz Flores
    Autonomous University of Baja California, Ensenada, Baja California 22860, Mexico. Electronic address: dflores@uabc.edu.mx.
  • Everardo Gutiérrez-López
    Universidad Autónoma de Baja California, Carretera Transpeninsular Ensenada-Tijuana 3917 Colonia Playitas, C.P. 22860, Ensenada, B.C., Mexico.
  • David Cervantes
    Autonomous University of Baja California, Ensenada, Baja California 22860, Mexico.
  • Patricia Juárez
    Centro de Investigación Científica y de Educación Superior de Ensenada, Carretera Ensenada-Tijuana No. 3918, Zona Playitas, C.P. 22860, Ensenada, B.C., Mexico.

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