Prediction of Citrullination Sites on the Basis of mRMR Method and SNN.
Journal:
Combinatorial chemistry & high throughput screening
PMID:
31782357
Abstract
BACKGROUND: Citrullination, an important post-translational modification of proteins, alters the molecular weight and electrostatic charge of the protein side chains. Citrulline, in protein sequences, is catalyzed by a class of Peptidyl Arginine Deiminases (PADs). Dependent on Ca2+, PADs include five isozymes: PAD 1, 2, 3, 4/5, and 6. Citrullinated proteins have been identified in many biological and pathological processes. Among them, abnormal protein citrullination modification can lead to serious human diseases, including multiple sclerosis and rheumatoid arthritis.