AIMC Topic: Citrulline

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Developing an explainable machine learning model to predict false-negative citrin deficiency cases in newborn screening.

Orphanet journal of rare diseases Oct 8, 2025
BACKGROUND: Neonatal Intrahepatic Cholestasis caused by Citrin Deficiency (NICCD) is an autosomal recessive disorder affecting the urea cycle and energy metabolism. Newborn screening (NBS) usually relies on elevated citrulline, but some patients have...
Humans Machine Learning Retrospective Studies Female Infant, Newborn Male Neonatal Screening Citrulline Citrullinemia
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Enteral versus parenteral nutrition in auto-HCT: a randomized controlled trial on clinical outcomes and gut microbiome dynamics.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Sep 19, 2025
Disruption of the gut microbiome is a common consequence of chemotherapy, linked with detrimental treatment outcomes (e.g. sepsis), especially in haematopoietic stem cell transplant (HCT) recipients. Preclinical data suggest that enteral nutrition (E...
Humans Machine Learning Female Aged Adult Male Middle Aged Treatment Outcome Gastrointestinal Microbiome Apoptosis Hematopoietic Stem Cell Transplantation Enteral Nutrition Citrulline Parenteral Nutrition
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Prediction of Citrullination Sites on the Basis of mRMR Method and SNN.

Combinatorial chemistry & high throughput screening Jan 1, 2019
BACKGROUND: Citrullination, an important post-translational modification of proteins, alters the molecular weight and electrostatic charge of the protein side chains. Citrulline, in protein sequences, is catalyzed by a class of Peptidyl Arginine Deim...
Humans Neural Networks, Computer Algorithms Computational Biology Citrullination Citrulline
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