Application of a long short-term memory neural network: a burgeoning method of deep learning in forecasting HIV incidence in Guangxi, China.

Journal: Epidemiology and infection
Published Date:

Abstract

Guangxi, a province in southwestern China, has the second highest reported number of HIV/AIDS cases in China. This study aimed to develop an accurate and effective model to describe the tendency of HIV and to predict its incidence in Guangxi. HIV incidence data of Guangxi from 2005 to 2016 were obtained from the database of the Chinese Center for Disease Control and Prevention. Long short-term memory (LSTM) neural network models, autoregressive integrated moving average (ARIMA) models, generalised regression neural network (GRNN) models and exponential smoothing (ES) were used to fit the incidence data. Data from 2015 and 2016 were used to validate the most suitable models. The model performances were evaluated by evaluating metrics, including mean square error (MSE), root mean square error, mean absolute error and mean absolute percentage error. The LSTM model had the lowest MSE when the N value (time step) was 12. The most appropriate ARIMA models for incidence in 2015 and 2016 were ARIMA (1, 1, 2) (0, 1, 2)12 and ARIMA (2, 1, 0) (1, 1, 2)12, respectively. The accuracy of GRNN and ES models in forecasting HIV incidence in Guangxi was relatively poor. Four performance metrics of the LSTM model were all lower than the ARIMA, GRNN and ES models. The LSTM model was more effective than other time-series models and is important for the monitoring and control of local HIV epidemics.

Authors

  • G Wang
  • W Wei
    Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University,Nanning 530021, Guangxi,China.
  • J Jiang
    Heart and Lung Centre, New Cross Hospital, Royal Wolverhampton NHS Trust, Wolverhampton, United Kingdom.
  • C Ning
    Guangxi Collaborative Innovation Center for Biomedicine,Life Science Institute,Guangxi Medical University,Nanning 530021, Guangxi,China.
  • H Chen
    Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • J Huang
    Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University,Nanning 530021, Guangxi,China.
  • B Liang
    Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University,Nanning 530021, Guangxi,China.
  • N Zang
    Guangxi Collaborative Innovation Center for Biomedicine,Life Science Institute,Guangxi Medical University,Nanning 530021, Guangxi,China.
  • Y Liao
    Guangxi Collaborative Innovation Center for Biomedicine,Life Science Institute,Guangxi Medical University,Nanning 530021, Guangxi,China.
  • R Chen
    Jiangsu Key Laboratory for Food Quality and Safety, State Key Laboratory Cultivation Base of Ministry of Science and Technology, Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, China.
  • J Lai
    Guangxi Collaborative Innovation Center for Biomedicine,Life Science Institute,Guangxi Medical University,Nanning 530021, Guangxi,China.
  • O Zhou
    Guangxi Collaborative Innovation Center for Biomedicine,Life Science Institute,Guangxi Medical University,Nanning 530021, Guangxi,China.
  • J Han
    Guangxi Collaborative Innovation Center for Biomedicine,Life Science Institute,Guangxi Medical University,Nanning 530021, Guangxi,China.
  • H Liang
    Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • L Ye
    Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University,Nanning 530021, Guangxi,China.