Evaluating the evidence for biotypes of depression: Methodological replication and extension of.

Journal: NeuroImage. Clinical
Published Date: Mar 27, 2019

Abstract

BACKGROUND: Psychiatric disorders are highly heterogeneous, defined based on symptoms with little connection to potential underlying biological mechanisms. A possible approach to dissect biological heterogeneity is to look for biologically meaningful subtypes. A recent study Drysdale et al. (2017) showed promising results along this line by simultaneously using resting state fMRI and clinical data and identified four distinct subtypes of depression with different clinical profiles and abnormal resting state fMRI connectivity. These subtypes were predictive of treatment response to transcranial magnetic stimulation therapy.

Authors

  • Richard Dinga
    Department of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
  • Lianne Schmaal
    Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
  • Brenda W J H Penninx
    Department of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
  • Marie Jose van Tol
    Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Dick J Veltman
    Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
  • Laura van Velzen
    Department of Psychiatry, Amsterdam UMC, Amsterdam, the Netherlands.
  • Maarten Mennes
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Nic J A van der Wee
    Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.
  • Andre F Marquand
    Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

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