Autophagy and Apoptosis Specific Knowledgebases-guided Systems Pharmacology Drug Research.
Journal:
Current cancer drug targets
Published Date:
Jan 1, 2019
Abstract
BACKGROUND: Autophagy and apoptosis are the basic physiological processes in cells that clean up aged and mutant cellular components or even the entire cells. Both autophagy and apoptosis are disrupted in most major diseases such as cancer and neurological disorders. Recently, increasing attention has been paid to understand the crosstalk between autophagy and apoptosis due to their tightly synergetic or opposite functions in several pathological processes.