Machine Learning Models for the Prediction of Chemotherapy-Induced Peripheral Neuropathy.
Journal:
Pharmaceutical research
Published Date:
Jan 7, 2019
Abstract
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse side effect of cancer chemotherapy that can be life debilitating and cause extreme pain. The multifactorial and poorly understood mechanisms of toxicity have impeded the identification of novel treatment strategies. Computational models of drug neurotoxicity could be implemented in early drug discovery to screen for high-risk compounds and select safer drug candidates for further development.