Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning.

Journal: AJNR. American journal of neuroradiology
Published Date:

Abstract

BACKGROUND AND PURPOSE: MR imaging-based modeling of tumor cell density can substantially improve targeted treatment of glioblastoma. Unfortunately, interpatient variability limits the predictive ability of many modeling approaches. We present a transfer learning method that generates individualized patient models, grounded in the wealth of population data, while also detecting and adjusting for interpatient variabilities based on each patient's own histologic data.

Authors

  • L S Hu
    From the Department of Radiology (L.S.H., J.M.H., J.R.M., T.W., J.L.) Hu.Leland@Mayo.Edu.
  • H Yoon
    Arizona State University (H.Y., Y.X., L.W., T.W., J.L.), Tempe, Arizona.
  • J M Eschbacher
    Departments of Pathology (J.M.E.).
  • L C Baxter
    Radiology (L.C.B., A.N., J.P.K.).
  • A C Dueck
    Department of Biostatistics (A.C.D.), Mayo Clinic in Arizona, Scottsdale, Arizona.
  • A Nespodzany
    Radiology (L.C.B., A.N., J.P.K.).
  • K A Smith
    Neurosurgery (K.A.S., P.N., N.S.).
  • P Nakaji
    Neurosurgery (K.A.S., P.N., N.S.).
  • Y Xu
    Department of Clinical Laboratory, Affiliated Tumor Hospital, Xinjiang Medical University, Ulumqi, China.
  • L Wang
    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Ministry of Health, Key Laboratory of Ministry of Education, Wuhan, China.
  • J P Karis
    Radiology (L.C.B., A.N., J.P.K.).
  • A J Hawkins-Daarud
    Precision Neurotherapeutics Lab (A.J.H.-D., K.W.S., P.R.J, B.R.B., K.R.S.).
  • K W Singleton
    Precision Neurotherapeutics Lab (A.J.H.-D., K.W.S., P.R.J, B.R.B., K.R.S.).
  • P R Jackson
    Precision Neurotherapeutics Lab (A.J.H.-D., K.W.S., P.R.J, B.R.B., K.R.S.).
  • B J Anderies
    Department of Neurosurgery (B.J.A., B.R.B., R.S.Z., M.G.S., P.E.K., C.K., K.R.S.).
  • B R Bendok
    Precision Neurotherapeutics Lab (A.J.H.-D., K.W.S., P.R.J, B.R.B., K.R.S.).
  • R S Zimmerman
    Department of Neurosurgery (B.J.A., B.R.B., R.S.Z., M.G.S., P.E.K., C.K., K.R.S.).
  • C Quarles
    Neuroimaging Research (C.Q.), Barrow Neurological Institute, Phoenix, Arizona.
  • A B Porter-Umphrey
    Department of Neuro-Oncology (A.B.P.-U., M.M.M., A.S.).
  • M M Mrugala
    Department of Neuro-Oncology (A.B.P.-U., M.M.M., A.S.).
  • A Sharma
    Department of Neuro-Oncology (A.B.P.-U., M.M.M., A.S.).
  • J M Hoxworth
    From the Department of Radiology (L.S.H., J.M.H., J.R.M., T.W., J.L.).
  • M G Sattur
    Department of Neurosurgery (B.J.A., B.R.B., R.S.Z., M.G.S., P.E.K., C.K., K.R.S.).
  • N Sanai
    Neurosurgery (K.A.S., P.N., N.S.).
  • P E Koulemberis
    Department of Neurosurgery (B.J.A., B.R.B., R.S.Z., M.G.S., P.E.K., C.K., K.R.S.).
  • C Krishna
    Department of Neurosurgery (B.J.A., B.R.B., R.S.Z., M.G.S., P.E.K., C.K., K.R.S.).
  • J R Mitchell
    From the Department of Radiology (L.S.H., J.M.H., J.R.M., T.W., J.L.).
  • T Wu
    From the Department of Radiology (L.S.H., J.M.H., J.R.M., T.W., J.L.).
  • N L Tran
    Department of Cancer Biology (N.L.T.), Mayo Clinic in Arizona, Phoenix, Arizona.
  • K R Swanson
    Precision Neurotherapeutics Lab (A.J.H.-D., K.W.S., P.R.J, B.R.B., K.R.S.).
  • J Li
    Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.