BIPSPI: a method for the prediction of partner-specific protein-protein interfaces.

Journal: Bioinformatics (Oxford, England)
Published Date: Feb 1, 2019

Abstract

MOTIVATION: Protein-Protein Interactions (PPI) are essentials for most cellular processes and thus, unveiling how proteins interact is a crucial question that can be better understood by identifying which residues are responsible for the interaction. Computational approaches are orders of magnitude cheaper and faster than experimental ones, leading to proliferation of multiple methods aimed to predict which residues belong to the interface of an interaction.

Authors

  • Ruben Sanchez-Garcia
    GN7 of the Spanish National Institute for Bioinformatics (INB), Biocomputing Unit, National Center of Biotechnology (CSIC), Instruct Image Processing Center, Madrid, Spain.
  • C O S Sorzano
    GN7 of the Spanish National Institute for Bioinformatics (INB), Biocomputing Unit, National Center of Biotechnology (CSIC), Instruct Image Processing Center, Madrid, Spain.
  • J M Carazo
    GN7 of the Spanish National Institute for Bioinformatics (INB), Biocomputing Unit, National Center of Biotechnology (CSIC), Instruct Image Processing Center, Madrid, Spain.
  • Joan Segura
    Research Collaboratory for Structural Bioinformatics Protein Data Bank, San Diego Supercomputer Center, University of California San Diego, San Diego, CA, United States.

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