KGDDS: A System for Drug-Drug Similarity Measure in Therapeutic Substitution based on Knowledge Graph Curation.
Journal:
Journal of medical systems
PMID:
30834481
Abstract
Measuring drug-drug similarity is important but challenging. Significant progresses have been made in drugs whose labeled training data is sufficient and available. However, handling data skewness and incompleteness with domain-specific knowledge graph, is still a relatively new territory and an under-explored prospect. In this paper, we present a system KGDDS for node-link-based bio-medical Knowledge Graph curation and visualization, aiding Drug-Drug Similarity measure. Specifically, we reuse existing knowledge bases to alleviate the difficulties in building a high-quality knowledge graph, ranging in size up to 7 million edges. Then we design a prediction model to explore the pharmacology features and knowledge graph features. Finally, we propose a user interaction model to allow the user to better understand the drug properties from a drug similarity perspective and gain insights that are not easily observable in individual drugs. Visual result demonstration and experimental results indicate that KGDDS can bridge the user/caregiver gap by facilitating antibiotics prescription knowledge, and has remarkable applicability, outperforming existing state-of-the-art drug similarity measures.