AIMC Topic: Drug Substitution

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Real-world faricimab switch in France: artificial intelligence-based detection of changes in exudative signs in difficult-to-treat neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 23, 2025
PURPOSE: Some patients with neovascular age-related macular degeneration (nAMD) have persistent signs of exudation under treatment with intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents. We examined the real-world anato...
Follow-Up Studies Visual Acuity Tomography, Optical Coherence Vascular Endothelial Growth Factor A Aged, 80 and over Male Angiogenesis Inhibitors Fluorescein Angiography Wet Macular Degeneration Antibodies, Bispecific Subretinal Fluid Drug Substitution France Exudates and Transudates Intravitreal Injections Humans Artificial Intelligence Retrospective Studies Female Aged
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Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β-agonist: post-hoc analyses of KRONOS.

Respiratory research May 8, 2025
BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/long-acting β-agonist (ICS/LABA) therapy, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends stepping up to ICS/long-acting mu...
Pulmonary Disease, Chronic Obstructive Male Middle Aged Treatment Outcome Humans Female Aged Muscarinic Antagonists Adrenal Cortex Hormones Administration, Inhalation Bronchodilator Agents Drug Combinations Double-Blind Method Drug Therapy, Combination Drug Substitution Adrenergic beta-2 Receptor Agonists
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KGDDS: A System for Drug-Drug Similarity Measure in Therapeutic Substitution based on Knowledge Graph Curation.

Journal of medical systems Mar 5, 2019
Measuring drug-drug similarity is important but challenging. Significant progresses have been made in drugs whose labeled training data is sufficient and available. However, handling data skewness and incompleteness with domain-specific knowledge gra...
Drug Substitution Audiovisual Aids Algorithms Humans Anti-Bacterial Agents Neural Networks, Computer User-Computer Interface Knowledge Bases
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Effect of Switching from Cilnidipine to Azelnidipine on Cardiac Sympathetic Nerve Function in Patients with Heart Failure Preserved Ejection Fraction.

International heart journal Dec 20, 2017
Cardiac sympathetic nerve activity is known to play a key role in the development and progression of heart failure (HF). Azelnidipine, an L-type calcium channel blocker (CCB), inhibits the sympathetic nerve activity of the central system. In contrast...
Aged, 80 and over Adult Male Stroke Volume Echocardiography Middle Aged Treatment Outcome Azetidinecarboxylic Acid Humans Dihydropyridines Retrospective Studies Heart Failure Sympathetic Nervous System Drug Substitution Follow-Up Studies Female Calcium Channel Blockers Dose-Response Relationship, Drug Aged Radionuclide Imaging Heart
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Imatinib Increases Serum Creatinine by Inhibiting Its Tubular Secretion in a Reversible Fashion in Chronic Myeloid Leukemia.

Clinical lymphoma, myeloma & leukemia Dec 20, 2015
BACKGROUND: Monitoring renal function is important in imatinib-treated patients with chronic myeloid leukemia because serum creatinine may increase during the course of therapy. The mechanism of this increase and its reversibility on treatment cessat...
Kidney Function Tests Creatinine Drug Substitution Imatinib Mesylate Protein Kinase Inhibitors Kidney Tubules Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antineoplastic Agents Case-Control Studies Treatment Outcome Glomerular Filtration Rate Adult Male Middle Aged Humans Retrospective Studies Female Aged Young Adult
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Principi di farmacodinamica e farmacocinetica nello switch tra antipsicotici: focus su cariprazina.

Rivista di psichiatria Jan 1, 2019
Cariprazina {RGH-188; trans-N- [4- [2- [4- (2,3-diclorofenil) piperazin-1-il] etil] cicloesil] -N_, N_-dimetilurea cloridrato} è un antipsicotico atipico di nuova generazione, con un originale profilo farmacodinamico e farmacocinetico. Cariprazina ha...
Antipsychotic Agents Cognition Disorders Cytochrome P-450 CYP2D6 Inducers Receptor, Serotonin, 5-HT2C Cytochrome P-450 CYP3A Inducers Drug Substitution Ketoconazole Receptor, Serotonin, 5-HT2A Humans Drug Interactions Time Factors Schizophrenia Piperazines Half-Life Anhedonia
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Real World Patient-reported Outcomes in HIV-infected Adults Switching to EVIPLERA®, Because of a Previous Intolerance to cART. PRO-STR Study.

Current HIV research Jan 1, 2018
BACKGROUND: To investigate the impact of switching from stable Combined Antiretroviral Therapy (cART) to single-tablet regimen (RPV/FTC/TDF=EVIPLERA® /COMPLERA®) on patient- reported outcomes in HIV-infected adults who cannot tolerate previous cART, ...
Antiretroviral Therapy, Highly Active Patient Reported Outcome Measures Drug Substitution Female Adult Male Middle Aged Humans Prospective Studies Quality of Life HIV Infections Viral Load Anti-HIV Agents Treatment Outcome Drug Combinations CD4 Lymphocyte Count
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