Deep learning and manual assessment show that the absolute mitotic count does not contain prognostic information in triple negative breast cancer.

Journal: Cellular oncology (Dordrecht, Netherlands)
PMID: 30989469

Abstract

PURPOSE: The prognostic value of mitotic count for invasive breast cancer is firmly established. As yet, however, limited studies have been aimed at assessing mitotic counts as a prognostic factor for triple negative breast cancers (TNBC). Here, we assessed the prognostic value of absolute mitotic counts for TNBC, using both deep learning and manual procedures.

Authors

  • Maschenka C A Balkenhol
    Department of Pathology, Radboud University Medical Center, PO Box 9100, 6500, HB, Nijmegen, the Netherlands. maschenka.balkenhol@radboudumc.nl.
  • Peter Bult
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • David Tellez
    Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Willem Vreuls
    Department of Pathology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
  • Pieter C Clahsen
    Department of Pathology, Haaglanden Medical Center, 's-Gravenhage, the Netherlands.
  • Francesco Ciompi
    Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: francesco.ciompi@radboudumc.nl.
  • Jeroen A W M van der Laak
    Diagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, The Netherlands.

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