Integrated analysis of single-cell RNA-seq and chipset data unravels PANoptosis-related genes in sepsis.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND: The poor prognosis of sepsis warrants the investigation of biomarkers for predicting the outcome. Several studies have indicated that PANoptosis exerts a critical role in tumor initiation and development. Nevertheless, the role of PANoptosis in sepsis has not been fully elucidated.

Authors

  • Wei Dai
    Department of Intensive Care Unit, The First Affiliated Hospital of Jiangxi Medical College, Shangrao, Jiangxi, China.
  • Ping Zheng
    Department of Key Laboratory, Shanghai Pudong New Area People's Hospital, Shanghai, China.
  • Jian Wu
    Department of Medical Technology, Jiangxi Medical College, Shangrao, Jiangxi, China.
  • Siqi Chen
    College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
  • Mingtao Deng
    Department of Medical Technology, Jiangxi Medical College, Shangrao, Jiangxi, China.
  • Xiangqian Tong
    Department of Intensive Care Unit, The First Affiliated Hospital of Jiangxi Medical College, Shangrao, Jiangxi, China.
  • Fen Liu
    Department of Intensive Care Unit, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
  • Xiuling Shang
    Department of Critical Care Medicine, Fujian Provincial Key Laboratory of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fuzhou, Fujian, China.
  • Kejian Qian
    Department of Intensive Care Unit, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.