Deep Learning to Therapeutically Target Unreported Complexes.
Journal:
Trends in pharmacological sciences
Published Date:
Aug 1, 2019
Abstract
The disruption of large protein-protein (PP) interfaces remains a challenge in targeted therapy. Designing drugs that compete with binding partners is daunting, especially when the structure of the protein complex is unknown. To address the problem we propose a deep protein databank (PDB) learning platform to discover targetable epitopes for complex-disruptive leads.