AIMC Topic: Molecular Targeted Therapy
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Advancements in lung cancer: molecular insights, innovative therapies, and future prospects.
Medical oncology (Northwood, London, England)
Jul 28, 2025
Still among the most common and deadly cancers worldwide, lung cancer causes major morbidity and death. Thanks to late-stage diagnosis, tumor heterogeneity, and resistance to traditional treatments, the prognosis for lung cancer patients is still poo...
Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing.
Journal of translational medicine
Jul 4, 2025
BACKGROUND: Diabetic kidney disease (DKD) is the major cause of chronic kidney failure, with tubulointerstitial fibrosis playing a crucial role in disease development. Identifying fibrosis-related genes is crucial for improving diagnosis and developi...
Advances in molecular pathology and therapy of non-small cell lung cancer.
Signal transduction and targeted therapy
Jun 15, 2025
Over the past two decades, non-small cell lung cancer (NSCLC) has witnessed encouraging advancements in basic and clinical research. However, substantial unmet needs remain for patients worldwide, as drug resistance persists as an inevitable reality....
The latest advances with natural products in drug discovery and opportunities for the future: a 2025 update.
Expert opinion on drug discovery
Jun 5, 2025
INTRODUCTION: The landscape of drug discovery is rapidly evolving, with natural products (NPs) playing a pivotal role in the development of novel therapeutics. Despite their historical significance, challenges persist in fully harnessing their potent...
Acquired resistance in cancer: towards targeted therapeutic strategies.
Nature reviews. Cancer
Jun 3, 2025
Development of acquired therapeutic resistance limits the efficacy of cancer treatments and accounts for therapeutic failure in most patients. How resistance arises, varies across cancer types and differs depending on therapeutic modalities is incomp...
Significance of NMDA receptor-targeting compounds in neuropsychological disorders: An in-depth review.
European journal of pharmacology
Apr 30, 2025
N-methyl-D-aspartate receptors (NMDARs), a subclass of glutamate-gated ion channels, play an integral role in the maintenance of synaptic plasticity and excitation-inhibition balance within the central nervous system (CNS). Any irregularities in NMDA...
Deep learning radiopathomics predicts targeted therapy sensitivity in EGFR-mutant lung adenocarcinoma.
Journal of translational medicine
Apr 29, 2025
BACKGROUND: Ttyrosine kinase inhibitors (TKIs) represent the standard first-line treatment for patients with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma. However, not all patients with EGFR mutations respond to TKIs. This study...
Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis.
Journal of dermatological science
Apr 26, 2025
BACKGROUND: The development of medical treatments has traditionally relied on researchers leveraging scientific knowledge to hypothesize disease mechanisms and identify therapeutic agents. However, the depletion of novel therapeutic targets has becom...
Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis.
Molecular neurobiology
Apr 11, 2025
Schizophrenia is a severe mental disorder characterized by oxidative stress imbalances. The underlying mechanisms of oxidative stress-related gene expression in schizophrenia require further investigation. Additionally, the diagnosis of schizophrenia...
Integrated AI and machine learning pipeline identifies novel WEE1 kinase inhibitors for targeted cancer therapy.
Molecular diversity
Mar 19, 2025
The dysregulation of the cell cycle in cancer underscores the therapeutic potential of targeting WEE1 kinase, a key regulator of the G2/M checkpoint. This study harnessed artificial intelligence (AI)-driven methodologies, particularly the MORLD platf...
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