Discriminant analysis and machine learning approach for evaluating and improving the performance of immunohistochemical algorithms for COO classification of DLBCL.

Journal: Journal of translational medicine
PMID: 31185999

Abstract

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) and non-germinal center-like (non-GCB) cell-of-origin groups, entities driven by different oncogenic pathways with different clinical outcomes. DLBCL classification by immunohistochemistry (IHC)-based decision tree algorithms is a simpler reported technique than gene expression profiling (GEP). There is a significant discrepancy between IHC-decision tree algorithms when they are compared to GEP.

Authors

  • Yocanxóchitl Perfecto-Avalos
    Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Ave. Eugenio Garza Sada 2501, 64849, Monterrey, NL, Mexico.
  • Alejandro Garcia-Gonzalez
    Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.
  • Ana Hernandez-Reynoso
    Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
  • Gildardo Sanchez-Ante
    Tecnológico de Monterrey, Campus Guadalajara, Computer Science Department, Av. Gral Ramon Corona 2514, Zapopan, Jal, Mexico. Electronic address: gildardo@itesm.mx.
  • Carlos Ortiz-Hidalgo
    Department of Pathology, Hospital y Fundación Medica Sur, 14050, Mexico City, Mexico.
  • Sean-Patrick Scott
    Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.
  • Rita Q Fuentes-Aguilar
    Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Ave. Eugenio Garza Sada 2501, 64849, Monterrey, NL, Mexico.
  • Ricardo Diaz-Dominguez
    Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.
  • Grettel León-Martínez
    Department of Pathology, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Hospital General Tacuba, Lago Ontario 36, Tacuba, 11410, Mexico City, Mexico.
  • Verónica Velasco-Vales
    Department of Pathology, Hospital Angeles Lomas, Col. Valle de las Palmas, Hacienda de las Palmas, 52763, Huixquilucan, Mexico.
  • Mara A Cárdenas-Escudero
    , Querétaro, Mexico.
  • José A Hernández-Hernández
    Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.
  • Arturo Santos
    Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.
  • José R Borbolla-Escoboza
    Novartis, East Hanover, NJ, USA.
  • Luis Villela
    Centro Médico "Dr. Ignacio Chávez". ISSSTESON, 83000, Hermosillo, SON, Mexico. doc.villela@yahoo.com.

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