AIMC Topic: Lymphoma, Large B-Cell, Diffuse
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Classification of patients with relapsed/refractory large B-cell lymphoma who do not develop early CRS/NE toxicity using ZUMA clinical trial data.
Journal for immunotherapy of cancer
Aug 4, 2025
BACKGROUND: We aimed to develop an actionable and feasible prospective clinical model to estimate toxicity risk to assist chimeric antigen receptor (CAR) T-cell therapy providers with the management of patients with relapsed and/or refractory large B...
Machine learning-based histopathological features of histological slides and clinical characteristics as a novel prognostic indicator in diffuse large B-cell lymphoma.
Pathology, research and practice
Jun 4, 2025
OBJECTIVE: This study developed and validated a deep learning model based on clinical and histopathological features for predicting the outcomes of diffuse large B-cell lymphoma (DLBCL).
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches.
Biology direct
Apr 29, 2025
M2 macrophages play a crucial role in the initiation and progression of various tumors, including diffuse large B-cell lymphoma (DLBCL). However, the characterization of M2 macrophage-related genes in DLBCL remains incomplete. In this study, we downl...
A novel cancer-associated fibroblast-related gene signature for predicting diffuse large B cell lymphoma prognosis using weighted gene co-expression network analysis and machine learning.
The Journal of international medical research
Apr 25, 2025
ObjectiveOur objective was to investigate a novel cancer-associated fibroblast-related gene signature for predicting clinical outcomes in patients with diffuse large B cell lymphoma.MethodsThe cancer-associated fibroblast-related module genes were id...
Nomograms
Cancer-Associated Fibroblasts
Lymphoma, Large B-Cell, Diffuse
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
Gene Expression Profiling
Humans
Retrospective Studies
Machine Learning
Transcriptome
Female
ROC Curve
Biomarkers, Tumor
Gene Regulatory Networks
Gene Expression Regulation, Neoplastic
Machine learning-based identification of cuproptosis-related lncRNA biomarkers in diffuse large B-cell lymphoma.
Cell biology and toxicology
Apr 21, 2025
Multiple machine learning techniques were employed to identify key long non-coding RNA (lncRNA) biomarkers associated with cuproptosis in Diffuse Large B-Cell Lymphoma (DLBCL). Data from the TCGA and GEO databases facilitated the identification of 12...
5-5-5 ABRT (Dose of 5 Gy per Fraction for up to 5 Fractions Over 5 Weeks Adaptive Bridging Radiation Therapy)-Artificial Intelligence Enters the CAR (-T) (Chimeric Antigen Receptor-T) in Relapsed/Refractory Large B Cell Lymphoma.
International journal of radiation oncology, biology, physics
Apr 3, 2025
PURPOSE: Bridging radiation therapy (BRT) is effective for local control in patients with relapsed or refractory large B cell lymphoma who are undergoing chimeric antigen receptor (CAR) T cell therapy. We hypothesized that adaptive BRT (ABRT), which ...
F-FDG PET radiomics score construction by automatic machine learning for treatment response prediction in elderly patients with diffuse large B-cell lymphoma: a multicenter study.
Journal of cancer research and clinical oncology
Mar 28, 2025
PURPOSE: To explore the development and validation of automated machine learning (AutoML) models for F-FDG PET imaging-based radiomics signatures to predict treatment response in elderly patients with diffuse large B-cell lymphoma (DLBCL).
Rituximab
Vincristine
Positron-Emission Tomography
Humans
Cyclophosphamide
Machine Learning
Fluorodeoxyglucose F18
Prednisone
Middle Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Radiomics
Treatment Outcome
Lymphoma, Large B-Cell, Diffuse
Radiopharmaceuticals
Male
Prognosis
Retrospective Studies
Female
Aged
Plasma Cytokine and Chemokine Profiles Predict Efficacy and Toxicity of Anti-CD19 CAR-T Cell Therapy in Large B-Cell Lymphoma.
Clinical lymphoma, myeloma & leukemia
Feb 20, 2025
BACKGROUND: Anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a promising treatment for large B-cell lymphoma (LBCL); however, durable complete responses are achieved in only 30% to 40% of patients. Additionally, CAR-T therapy...
A multi-view prognostic model for diffuse large B-cell lymphoma based on kernel canonical correlation analysis and support vector machine.
BMC cancer
Dec 5, 2024
BACKGROUND AND OBJECTIVE: Positron emission tomography/computed tomography (PET/CT) is recommended as the standard imaging modality for diffuse large B-cell lymphoma (DLBCL) staging. However, many studies have neglected the role of patients' prognost...
Identification of ferroptosis-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches.
International journal of biological macromolecules
Oct 31, 2024
Ferroptosis has emerged as a critical mechanism in the development and progression of various tumors, particularly diffuse large B-cell lymphoma (DLBCL). However, the thorough characterization of ferroptosis-related genes in DLBCL remains inadequatel...
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